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). The protein-DNA interface involves intensive DNA contacts with the NTase, OB, and HhH domains over a 19-bp segment of duplex DNA centered with regards to the nick (supplemental Fig. S3). The NTase domain binds into the damaged DNA strands at and flanking the nick; the OB area contacts the continual template strand encompassing the nick; along with the HhH domain binds equally strands over the small groove on the periphery of the footprint.
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, involving the NTase More at https://ligaz.bet/ and HhH domains. According to offered structural details, it is obvious that DNA ligases have advanced a minimum of 3 unique means of encircling DNA.
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